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Mohanty, Partha, Naaz, Farah, Kumar Bansal, Avi, Datta Gupta, Umesh. (1396). Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study. , 6(3), 113-122. doi: 10.22099/mbrc.2017.4084
Partha Mohanty; Farah Naaz; Avi Kumar Bansal; Umesh Datta Gupta. "Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study". , 6, 3, 1396, 113-122. doi: 10.22099/mbrc.2017.4084
Mohanty, Partha, Naaz, Farah, Kumar Bansal, Avi, Datta Gupta, Umesh. (1396). 'Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study', , 6(3), pp. 113-122. doi: 10.22099/mbrc.2017.4084
Mohanty, Partha, Naaz, Farah, Kumar Bansal, Avi, Datta Gupta, Umesh. Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study. , 1396; 6(3): 113-122. doi: 10.22099/mbrc.2017.4084

Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study

Molecular Biology Research Communications
مقاله 3، دوره 6، شماره 3، 2017، صفحه 113-122    اصل مقاله (294.01 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2017.4084
نویسندگان
Partha Mohanty1؛ Farah Naaz1؛ Avi Kumar Bansal2؛ Umesh Datta Gupta* 3
1Microbiology and Molecular Biology National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India
2Medical Division National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India
3National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India
چکیده
The emergence of drug resistance in leprosy is a major hurdle in leprosy elimination programme. Although the problem of drug resistance is presently not acute, it is important that we collect data more systematically and monitor the trend carefully so that effective measures to combat this problem can be developed. The present study aimed at the explication of cross resistance of rifabutin and rifapentine to rifampicin which would be helpful to programme managers for implementing rifabutin or rifapentine in replace of rifampicin. In this study we built 3D model of the M. leprae rpoB using Swiss Model and the modelled structure was docked with rifampicin, rifabutin and rifapentine. We established that these 3 antibiotics interact with the same binding region in the modelled rpoB of M. leprae. Thus we conclude that vocation of rifabutin and rifapentine could not be suitable in replace of rifampicin to combat with drug resistance leprosy.
کلیدواژه‌ها
Rifampicin؛ Rifabutin؛ Rifapentine؛ Leprosy؛ Drug Resistance؛ Docking
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