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Jamhiri, Iman, Saadat, Iraj, Omidvari, Shahpour. (1396). Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer. , 6(2), 85-90. doi: 10.22099/mbrc.2017.4059
Iman Jamhiri; Iraj Saadat; Shahpour Omidvari. "Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer". , 6, 2, 1396, 85-90. doi: 10.22099/mbrc.2017.4059
Jamhiri, Iman, Saadat, Iraj, Omidvari, Shahpour. (1396). 'Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer', , 6(2), pp. 85-90. doi: 10.22099/mbrc.2017.4059
Jamhiri, Iman, Saadat, Iraj, Omidvari, Shahpour. Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer. , 1396; 6(2): 85-90. doi: 10.22099/mbrc.2017.4059

Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer

Molecular Biology Research Communications
مقاله 5، دوره 6، شماره 2، 2017، صفحه 85-90    اصل مقاله (90.18 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2017.4059
نویسندگان
Iman Jamhiri1؛ Iraj Saadat* 1؛ Shahpour Omidvari2
1Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
2Department of Chemotherapy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles can be established as risk factors for some kind of multi-factorial diseases including cancer. In present study we investigate the possible association between polymorphisms of superoxide dismutase 1 (SOD1, OMIM: 147450) and catalase (CAT, OMIM: 115500) genes and the risk of colorectal cancer (CRC). The study included 204 colorectal cancer patients and 239 healthy control group matched for gender and age. Genotyping of SOD1 A251G and CAT C-262T were done by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. There was no significant association between CAT C-262T polymorphism and susceptibility to CRC (P>0.05). The carries of the G allele of SOD1 significantly showed higher prevalence in CRC patients compared with the control group (OR=1.84, 95% CI=1.13-2.98, P=0.013). We assessed the effect of combination of genotypes of the study polymorphisms on the risk of CRC. We found that the combination of AG+GG (SOD1) and CC (CAT) increases the risk of developing CRC (OR=2.38, 95% CI=1.25-4.52, P=0.008).
کلیدواژه‌ها
SOD1؛ Catalase؛ Colorectal cancer؛ Genetic polymorphism
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