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Sadiq, Nida, Javid, Bhat, Akbar, Masood, Idrees, Shah, Adil, Wani, Bashi Ahmad, Ganai. (1396). Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India. , 6(2), 77-84. doi: 10.22099/mbrc.2017.4058
Nida Sadiq; Bhat Javid; Masood Akbar; Shah Idrees; Wani Adil; Ganai Bashi Ahmad. "Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India". , 6, 2, 1396, 77-84. doi: 10.22099/mbrc.2017.4058
Sadiq, Nida, Javid, Bhat, Akbar, Masood, Idrees, Shah, Adil, Wani, Bashi Ahmad, Ganai. (1396). 'Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India', , 6(2), pp. 77-84. doi: 10.22099/mbrc.2017.4058
Sadiq, Nida, Javid, Bhat, Akbar, Masood, Idrees, Shah, Adil, Wani, Bashi Ahmad, Ganai. Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India. , 1396; 6(2): 77-84. doi: 10.22099/mbrc.2017.4058

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Molecular Biology Research Communications
مقاله 4، دوره 6، شماره 2، 2017، صفحه 77-84    اصل مقاله (138.77 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2017.4058
نویسندگان
Nida Sadiq* 1؛ Bhat Javid2؛ Masood Akbar1؛ Shah Idrees1؛ Wani Adil1؛ Ganai Bashi Ahmad3
1Department of Biochemistry, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
2Department of Clinical Heamatology, Sher-e-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, India
3Center of Research Development (CORD), University of Kashmir Srinagar, Jammu and Kashmir, India
چکیده
Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL cases, and an equal number of controls, matched for sex, age and district of residence to the respective case. Information was obtained on various lifestyle and environmental factors in face to face interviews with the parents/attendants of each subject. Genotypes of CYP1A1 and CYP2D6 were analyzed by polymerase chain reaction and restriction fragment length polymorphism method. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Compared to the GG genotype, we found a higher ALL risk in subjects who harbored variant (AA) genotype (OR=20.9; 95% CI: 6.01-73.1, P<0.0001) and AG genotype (OR=42.6; 95% CI: 8.3-217.5, P<0.0001) of CYP2D6*4 polymorphism. Although, we found a significant association of CYP1A1*2A polymorphism with ALL risk, but the risk did not persist in the adjusted model (OR=6.76; 95% CI: 0.63–71.8, P=0.100). The study indicates that unlike CYP1A1*2A, CYP2D6*4 polymorphism is associated with ALL risk. However, more replicative studies with larger sample size are needed to substantiate our findings.
کلیدواژه‌ها
Acute Lymphoblastic Leukaemia؛ Polymorphism؛ Kashmir؛ Xenobiotics
مراجع

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