| تعداد نشریات | 24 |
| تعداد شماره‌ها | 859 |
| تعداد مقالات | 7,631 |
| تعداد مشاهده مقاله | 13,515,248 |
| تعداد دریافت فایل اصل مقاله | 11,637,833 |
The effects of sub-chronic administration of sub-lethal doses of amitraz/xylene on selected reproductive parameters of male Wistar rats | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 11، دوره 17، شماره 4 - شماره پیاپی 57، 2016، صفحه 277-280 اصل مقاله (282.67 K) | ||
| نوع مقاله: Short paper | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2016.3917 | ||
| نویسندگان | ||
| V. U. Omoja* 1؛ S. M. Anika1؛ I. U. Asuzu2 | ||
| 1Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka Enugu State, Nigeria | ||
| 2Office of the Vice-Chancellor, Federal University Oye-Ekiti, Ekiti State, Nigeria | ||
| چکیده | ||
| This study investigated the effects of sub-chronic administration of sub-lethal doses of amitraz on some testicular parameters of Albino rats. Twenty-four adult male Albino rats (100 ± 10 g) randomly assigned into four groups were used for the study. Groups A, B and C received 10.0, 2.0 and 0.4 mg/kg amitraz in 10 ml/kg water while group D received equivalent volume of water orally and daily for 84 days. Serum testosterone levels (TESL) were assessed on days 0, 28, 56 and 84. Epididymal sperm reserve (ESR), testicular sperm reserve (TSR), testicular weight index (TWI) and testicular histology were evaluated at the end of the experiment. Results revealed dose-dependent reduction (P<0.05) in the mean TESL, ESR and TSR in the amitraz-treated groups as the dose of the amitraz increased. Histological study revealed testicular degeneration characterized by depopulation of seminiferous tubules and depletion of the spermatogenic cells in rats in group A. It was concluded that sub-chronic administration of sub-lethal doses of amitraz could lead to reduced sperm quantity. | ||
| کلیدواژه‌ها | ||
| Amitraz؛ Rat؛ Sperm؛ Testis؛ Testosterone | ||
| مراجع | ||
|
Bancroft, JD and Stevens, A (1977). Theory and practice of histological techniques. 1st Edn., Edinburgh, Churchill Livingstone. PP: 16-64.
Bukowska, B (2003). Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes. Comp. Biochem. Physiol. C Comp. Pharmacol., 135: 435-441.
Chatfield, C (1983). Statistics for technology: a course in applied statistics. 3rd Edn., London, Chapman and Hull. P: 140.
Crofton, KM; Boncek, VM and Reiter, LW (1989). Acute effects of amitraz on the acoustic startle response and motor activity. Pestic. Sci., 27: 1-11.
Gwaltney-Brant, S (2004). Insecticides and molluscicides. Clinical veterinary toxicology. (1st Edn.), USA, Konnie Plumlee, Mosby Inc., PP: 177-178.
Hsu, WH and Schaffer, DD (1988). Effects of topical application of amitraz on plasma glucose and insulin concentrations in dogs. Am. J. Vet. Res., 49: 130-131.
Jonsson, NN; Miller, RJ; Kempc, DH; Knowles, A; Ardila, AE; Verrall, RG and Rothwell, JT (2010). Rotation of treatments between spinosad and amitraz for the control of Rhipicephalus (Boophilus) microplus populations with amitraz resistance. Vet. Parasitol., 169: 157-164.
Kruk, I and Bounias, M (1992). Chemiluminescence from oxidation of formamidine amitraz. The generation of cytotoxic oxygen species and electronically excited com-pounds. Sci. Total Environ., 123-124: 195-203.
Mills, T; Stopper, V and Wiedmeier, V (2004). Effects of castration and androgen replacement on the hemodynamics of penile erection in the rat. Biol. Reprod., 54: 234-238.
Nicolas, B; Andrew, YL; Robert, JM; Huguette, G; Jean-Michel, D; Ronald, BD and John, EG (2008). In vitro and in vivo evaluation of deltamethrin and amitraz mixtures for the control of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) in New Caledonia. Vet. Parasitol., 155: 110-119.
Oishi, S (2002). Effects of propylparaben on the male re-productive system. Food Chem. Toxicol., 40: 1807-1813.
Omoja, VU (2015). Amitraz toxicity, effect of vitamin C in amitraz-induced poisoning in rats and tissue levels of amitraz in exposed West African Dwarf sheep. Ph.D. Thesis, University of Nigeria, Nsukka. P: 61.
Omoja, VU; Asuzu, IU and Anika, SM (2015). Assessment of the hepatic and renal effects of sub-chronic administra-tion of sub-lethal doses of amitraz/xylene in Albino Wister rats. Comp. Clin. Pathol., 25: 203-209.
Shabsigh, R (2005). Testosterone therapy in erectile dysfunc-tion and hypogonadism. J. Sex. Med., 2: 785-792.
Soberans, NC; Santamaria, MV; Fragoso, HS and Garcia, ZV (2002). First case reported of amitraz resistance in the cattle tick Boophilus microplus in Mexico. Tec. Pecu. Mex., 40: 81-92.
Ueng, TH; Hung, CC; Wang, HW and Chan, PK (2004). Effects of amitraz on cytochrome P450-dependent mono-oxygenases and estrogenic activity in MCF-7 human breast cancer cells and immature female rats. Food Chem. Toxicol., 42: 1785-1794. | ||
|
آمار تعداد مشاهده مقاله: 1,334 تعداد دریافت فایل اصل مقاله: 774 |
||