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Immunohistochemical characterization of sebaceous epithelioma in two dogs | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 10، دوره 17، شماره 2 - شماره پیاپی 55، 2016، صفحه 134-136 اصل مقاله (302.29 K) | ||
| نوع مقاله: Scientific report | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2016.3739 | ||
| نویسندگان | ||
| J. S. Yoon1؛ J. Park* 2 | ||
| 1Biomedical Research Institute, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, Korea | ||
| 2Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Korea | ||
| چکیده | ||
| This report describes two cases of sebaceous epithelioma and its immunohistochemical characterization with CK 14, CK18, p63, Ki67 and Bcl-2 immunostaining. Case 1 was a 12-year-old, intact English Cocker spaniel female presenting with multiple skin nodules over one year. Case 2 was a 7-year-old, spayed poodle female with a five-month history of solitary mass. Hematoxylin and eosin (H&E) staining showed that the nodules in both cases were irregular lobules comprised of epithelial cells around well-differentiated sebocytes. Neoplastic cells were positive for CK14 and p63 but were negative for CK18 cell marker. In addition, immunostaining for Ki67 proliferation marker showed 13.1% and 12.4% positive cells in the two cases, respectively. Furthermore, Bcl-2, which is highly expressed in human benign sebaceous tumors, was seen in basaloid cell nuclei and cytoplasm. CK14, CK18, p63, Ki67, and Bcl-2 antibody application provided further information for diagnosing sebaceous epithelioma and for prognosis in these two cases. | ||
| کلیدواژهها | ||
| Bcl-2؛ Cytokeratin؛ dog؛ Immunohistochemistry؛ Sebaceous epithelioma | ||
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