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Non-clonal dissemination of Extended-spectrum beta lactamase-producing Pseudomonas aeruginosa strains of clinical origin | ||
| Iranian Journal of Science | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 14 دی 1394 | ||
| نوع مقاله: Regular Paper | ||
| شناسه دیجیتال (DOI): 10.22099/ijsts.2016.3506 | ||
| نویسندگان | ||
| Sibhghatulla Shaikh1؛ Syed Mohd. Danish Rizvi1؛ Shazi Shakil* 2؛ Neelam Pathak1؛ Adnan Ahmad3 | ||
| 1Department of Biosciences, Integral University, Lucknow-226026, India | ||
| 2KACST Technology Innovation Center for Personalized Medicine at King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 3Department of Bio-engineering, Integral University, Lucknow | ||
| چکیده | ||
| Monitoring the emergence and transmission of Pseudomonas aeruginosa strains is important for infection control worldwide. The aim of this study was to determine the genetic diversity of 47 extended spectrum beta-lactamase producing P. aeruginosa strains of clinical origin by enterobacterial repetitive intergenic consensus PCR (ERIC-PCR) and also to ascertain the presence of class 1 integrons amongst them. ERIC sequences are 127-bp imperfect palindromes that occur in multiple copies in the genomes of enteric bacteria. The ERIC-PCR profile generated showed polymorphism in the studied strains. Based on the ERIC-PCR profile, P. aeruginosa strains were grouped into 23 types. The major genotype designated as type L1, accounted for 10.6% (5/47) of samples. Class 1 integrons were detected in 8 of the 47 clinical isolates. Further, the integron-carrying isolates were found to display higher minimum inhibitory concentration against tested antibiotics. Optimization of antimicrobial use and control of infection is recommended to prevent the increase in the population of drug resistant organisms. | ||
| کلیدواژهها | ||
| Antibiotics؛ Epidemiology؛ Extended spectrum beta-lactamase؛ Enterobacterial repetitive intergenic consensus؛ Integrons؛ Pseudomonas aeruginosa | ||
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