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Behbahani, Parisima, Kazemi Nezhad, Seyed Reza, Foroughmand, Ali Mohammad, Ahmadi, Leila. (1394). Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran. , 4(2), 67-72. doi: 10.22099/mbrc.2015.2962
Parisima Behbahani; Seyed Reza Kazemi Nezhad; Ali Mohammad Foroughmand; Leila Ahmadi. "Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran". , 4, 2, 1394, 67-72. doi: 10.22099/mbrc.2015.2962
Behbahani, Parisima, Kazemi Nezhad, Seyed Reza, Foroughmand, Ali Mohammad, Ahmadi, Leila. (1394). 'Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran', , 4(2), pp. 67-72. doi: 10.22099/mbrc.2015.2962
Behbahani, Parisima, Kazemi Nezhad, Seyed Reza, Foroughmand, Ali Mohammad, Ahmadi, Leila. Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran. , 1394; 4(2): 67-72. doi: 10.22099/mbrc.2015.2962

Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran

Molecular Biology Research Communications
مقاله 2، دوره 4، شماره 2، شهریور 2015، صفحه 67-72    اصل مقاله (270.5 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2015.2962
نویسندگان
Parisima Behbahani؛ Seyed Reza Kazemi Nezhad* ؛ Ali Mohammad Foroughmand؛ Leila Ahmadi
Department of Genetics, Faculty of Science, Shahid Chamran University, Ahvaz, Iran
چکیده
Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association between the mentioned disorders and a genetic polymorphism (rs165599) of catechol O-methyltransferase (COMT, OMIM: 116790) was studied. Here 100 BPD patients, 100 SCZ patients, and 100 healthy controls were included in the study. The samples were matched in terms of gender and ethnicity. Statistical analysis showed that there was a significant association this polymorphism and risk of SCZ. The AG (OR=7.41, 95% CI: 3.21-17.1, P
کلیدواژه‌ها
Bipolar mood disorder؛ COMT gene؛ rs165599؛ Schizophrenia
مراجع

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