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Distribution of ACE insertion/deletion (I/D) polymorphism in Iranian populations | ||
| Molecular Biology Research Communications | ||
| مقاله 1، دوره 4، شماره 2، شهریور 2015، صفحه 63-66 اصل مقاله (162.49 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2015.2960 | ||
| نویسنده | ||
| Mostafa Saadat* | ||
| Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran | ||
| چکیده | ||
| Angiotensin converting enzyme (ACE; OMIM: 106180) has an important role in the conversion of angiotensin I to angiotensin II and degradation of bradykinin. Genetic polymorphism I/D (rs4646994) in the gene encoding ACE has been well defined. To get more insight into the genetic structure of Iranian populations, the distribution of the ACE I/D polymorphism among Iranians was compared with each other and with other populations. Prevalence of the D allele was 0.5886 (95% CI: 0.5725-0.6047) in Iran. There was significant difference between Iranian populations (Chi2=27.7, df=6, P2=10.15, df=5, P=0.071). The D allele showed high frequency in Iran which is similar to Caucasians. | ||
| کلیدواژهها | ||
| ACE؛ Iran؛ Polymorphism؛ Population genetics | ||
| مراجع | ||
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