اخبار و اعلانات

 آمار

تعداد نشریات24
تعداد شماره‌ها924
تعداد مقالات8,295
تعداد مشاهده مقاله16,557,524
تعداد دریافت فایل اصل مقاله13,967,345
Salehi, Abdolreza, Sobhani, Rohallah, Aminafshar, Mahdi, Sayyadnejhad, Mohammad, Nasiri, Khadijeh. (1393). Single nucleotide polymorphism of FGF2 gene in Iranian Holstein proven bulls. , 4(1), 57-62. doi: 10.22099/mbrc.2015.2916
Abdolreza Salehi; Rohallah Sobhani; Mahdi Aminafshar; Mohammad Sayyadnejhad; Khadijeh Nasiri. "Single nucleotide polymorphism of FGF2 gene in Iranian Holstein proven bulls". , 4, 1, 1393, 57-62. doi: 10.22099/mbrc.2015.2916
Salehi, Abdolreza, Sobhani, Rohallah, Aminafshar, Mahdi, Sayyadnejhad, Mohammad, Nasiri, Khadijeh. (1393). 'Single nucleotide polymorphism of FGF2 gene in Iranian Holstein proven bulls', , 4(1), pp. 57-62. doi: 10.22099/mbrc.2015.2916
Salehi, Abdolreza, Sobhani, Rohallah, Aminafshar, Mahdi, Sayyadnejhad, Mohammad, Nasiri, Khadijeh. Single nucleotide polymorphism of FGF2 gene in Iranian Holstein proven bulls. , 1393; 4(1): 57-62. doi: 10.22099/mbrc.2015.2916

Single nucleotide polymorphism of FGF2 gene in Iranian Holstein proven bulls

Molecular Biology Research Communications
مقاله 6، دوره 4، شماره 1، خرداد 2015، صفحه 57-62    اصل مقاله (277.67 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22099/mbrc.2015.2916
نویسندگان
Abdolreza Salehi* 1؛ Rohallah Sobhani2؛ Mahdi Aminafshar3؛ Mohammad Sayyadnejhad4؛ Khadijeh Nasiri2
1Department of Animal and Poultry Science, College of Abouraihan, University of Tehran, Iran
2Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Tehran, Pakdasht, Islamic Republic of Iran.
3Department of Animal Science, Faculty of Agriculture and Natural Resources, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran
4Animal Breeding Center of Iran, Karaj, Islamic Republic of Iran
چکیده
Fibroblast growth factor 2 (FGF2) serves in the uterine endometrium during estrous presenting in the bovine mammary gland which is responsible to express interferon-T (IFNT), and is an important agent to encourage the continuation of pregnancy in the ruminants. Significant associations have been found between genes affected by IFNT and genes that are responsible for milk production traits. Semen samples from 101 Iranian Holstein proven bulls were collected to extract the genomic DNA. Forward and reverse primers were designed and a 710-base-pair fragment in intron 1 was amplified using PCR technique. To detect single nucleotide polymorphism (SNP), all samples were sequenced. Three positions including 11474 (C/G), 11513 (C/G) and 11646 (A/G) were considered. The 11474C, 11513C and 11646A alleles are known as wild type alleles. In this study all animals were distinguished as the11474C, 11513C and 11646A alleles. Furthermore, amplified fragments were under consideration to detect new SNPs. Only one new SNP in one sample was observed at position 11863 resulting substitution of thymine to cytosine. This new mutation has been registered on the NCBI database with accession number HM597774.
کلیدواژه‌ها
FGF2؛ SNP؛ Iranian Holstein؛ Polymorphism؛ Candidate gene
مراجع
  1. Berisha B, Sinowatz F, Schams D. Expression and localization of fibroblast growth factor (FGF) family members during the final growth of bovine ovarian follicles. Molecular Reproduction and Development. 2004; 67: 162–171.
  2. Cobanoglu O, Zaitoun I, Chang Y M, Shook G E, Khatib H. Effects of the signal transducer and activator of transcription1 (STAT1) gene on milk production traits in Holstein dairy cattle. J Dairy Sci 2006; 89: 4433–4437. 
  3. Daniels R, Hall V, Trounson A O. Analysis of gene transcription in bovine nuclear transfer embryos reconstructed with granulose cell nuclei. Boil. Repord, 2000; 63: 1034-1040.
  4. Grisart B, Coppieters W, Farnir F, Karim L, Ford C 2002 Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res 12: 222-231.
  5. Khatib H, Schutzkus V, Chang Y M, Rosa G J M. Pattern of expression of the uterine milk protein gene and its association with productive life in dairy cattle. J Dairy Sci 2007a; 90: 2427–2433.
  6. Khatib H, Zaitoun I, Wiebelhaus-Finger J, Chang Y M, Rosa G J M. The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations. J Dairy Sci 2007b; 90: 2966–2970.
  7. Khatkar M S , Thomson P C, Tammen I, and Raadsma H W. Quantitative trait loci mapping in dairy cattle: Review and meta-analysis. Genet Sel Evol 2004; 36: 163–190.
  8. Lazzari G, Wrenzycki C, Herrmann D, Duchi R, Kruip T, Niemann H, Galli C. Cellular and molecular deviations in bovine in vitro-produced embryos are related to the large offspring syndrome. Biol Reprod 2002; 67: 767-775.
  9. Leonard S, Khatib H, Schutzkus V, Chang YM, Maltecca C. Effects of the osteopontin gene variants on milk production traits in dairy cattle. J Dairy Sci 2005; 88: 4083–4086.
  10. Michael D D, Alvarex, I M, Oco´n, O M, Powell A M., Talbot, N.C., Johnson, S.E., Ealy, A.D. Fibroblast growth factor-2 is expressed by the bovine uterus and stimulates interferon-tau production in bovine trophectoderm. Endocrinology. 2006; 147: 3571– 3579.
  11. Mousavizadeh, S A, Salehi A, Aminafshar M, Sayyadnejad M B, Nazemshirazi M H 2013. Novel SNPs of the ABCG2 Gene and Their Associations with Milk Production Traits in Iranian Holstein Bulls. J Agr Sci Tech. (2013) Vol. 15: 1145-1151.
  12. Oco´n-Grove, O M, Cooke F N, Alvarez, I M, Johnson S E, Ott, TL, Ealy, A D Ovine endometrial expression of fibroblast growth factor (FGF) 2 and conceptus expression of FGF receptors during early pregnancy. Domest  Anim  Endocrinol 2008; 34: 135-145.
  13. Ornitz D M, Itoh N Fibroblast growth factors. Genome Biol2. 200; 1REVIEWS3005.
  14. Plath A, Einspanier R, Gabler C, Peters F, Sinowatz F, Gospodarowicz D, Schams D. Expression and localization of members of the fibroblast growth factor family in the bovine mammary gland. J Dairy Sci 1998; 81: 2604-2613.
  15. Stewart MD, Choi Y, Johnson G A, Yu-Lee L Y, Bazer F W, Spencer T E Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF -1. Biol Reprod 2002; 66: 393–400.
  16. Wang X, Maltecca C, Tal-Steln R, Llpkln E, Khatib H. Association of Bovine Fibroblast Growth Factor 2 (FGF2) Gene with Milk Fat and Productive Life: An Example of the Ability of the Candidate Pathway Strategy to Identify Quantitative Trait Genes. J Dairy Sci 2008; 91: 2475-2480.
آمار
تعداد مشاهده مقاله: 5,294
تعداد دریافت فایل اصل مقاله: 3,834


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب