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Cadmium as an etiology of sperm dysfunction in Holstein bulls | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 6، دوره 7، شماره 3 - شماره پیاپی 16، 2006، صفحه 29-36 اصل مقاله (54.83 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2006.2646 | ||
| نویسنده | ||
| M. Arabi* | ||
| Department of Biology, Faculty of Basic Sciences, University of Shahrekord, Shahrekord, Iran | ||
| چکیده | ||
| Oxidative stress has been identified as a crucial factor leading to male infertility largely due to peroxidative damage to the sperm cell membrane. Cadmium (Cd) is a widespread environmental pollutant and one of the well-known reproductive toxicants. Because of its long biological half-life (10–30 years), Cd accumulates in the biological systems. The present study was designed to assess the concentration-dependent in vitro effect of 20 to 700 μM of Cd on the membrane integrity, motility, and acrosomal status of Holstein bull spermatozoa. We recorded a significant elevation in the malondialdehyde (MDA) level, increased lipid peroxidation (LPO) rate and a drastic decrease in the spermatocrit values, especially at the 700 μM concentration of Cd, indicating deleterious effects of Cd on the intactness of the sperm membrane. There was also a negative correlation between the LPO rate and both the percentage of motile spermatozoa (r = -0.89) and sperm viability (r = -0.86). Performing the gelatin test indicated that Cd altered the integrity of acrosomal membranes and showed an abnormal acrosome reaction. In this regard, a reverse correlation was found between the LPO rate and the percentage of halos (r = -0.96). In conclusion, Cd was proved to be a potential toxicant in the category of environmental factors that induced membrane impairments, lowered motility and viability, and decreased rate of acrosome reactions leading to bull sperm dysfunction. | ||
| کلیدواژهها | ||
| cadmium؛ Bull sperm؛ Membrane integrity؛ Motility؛ Acrosome | ||
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