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Kumar, A., Dey, S., Mahendran, K., Dan, A., Mahajan, S., Saxena, A.. (1393). Comparative assessment of N-terminal pro-B-type natriuretic peptide, nitric oxide and echocardiography for diagnosis of dilated cardiomyopathy in dogs. , 15(3), 233-237. doi: 10.22099/ijvr.2014.2532
A. Kumar; S. Dey; K. Mahendran; A. Dan; S. Mahajan; A. Saxena. "Comparative assessment of N-terminal pro-B-type natriuretic peptide, nitric oxide and echocardiography for diagnosis of dilated cardiomyopathy in dogs". , 15, 3, 1393, 233-237. doi: 10.22099/ijvr.2014.2532
Kumar, A., Dey, S., Mahendran, K., Dan, A., Mahajan, S., Saxena, A.. (1393). 'Comparative assessment of N-terminal pro-B-type natriuretic peptide, nitric oxide and echocardiography for diagnosis of dilated cardiomyopathy in dogs', , 15(3), pp. 233-237. doi: 10.22099/ijvr.2014.2532
Kumar, A., Dey, S., Mahendran, K., Dan, A., Mahajan, S., Saxena, A.. Comparative assessment of N-terminal pro-B-type natriuretic peptide, nitric oxide and echocardiography for diagnosis of dilated cardiomyopathy in dogs. , 1393; 15(3): 233-237. doi: 10.22099/ijvr.2014.2532

Comparative assessment of N-terminal pro-B-type natriuretic peptide, nitric oxide and echocardiography for diagnosis of dilated cardiomyopathy in dogs

Iranian Journal of Veterinary Research
مقاله 7، دوره 15، شماره 3 - شماره پیاپی 48، 2014، صفحه 233-237    اصل مقاله (120.13 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2014.2532
نویسندگان
A. Kumar1؛ S. Dey* 2؛ K. Mahendran3؛ A. Dan2؛ S. Mahajan1؛ A. Saxena4
1Ph.D. Student, Laboratory of Comparative System of Medicine, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP-243122, India
2Laboratory of Comparative System of Medicine, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP-243122, India
3Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP-243122, India
4Division of Surgery, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP-243122, India
چکیده
The aim of the study was to evaluate the clinical usefulness of N-terminal pro-brain natriuretic peptide (NT-Pro BNP) and nitric oxide (NO) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. Out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. Significant (P<0.01) increase in plasma NT-Pro BNP was found in dogs with cardiomyopathies. The plasma concentration of NO showed non-significant increase in comparison to healthy dogs. The sensitivity of NT-Pro BNP and NO was 72.20% and 62.50%, with specificity 93.90% and 89.40%, respectively when compared with echocardiography. The correlation between echocardiography and NT-Pro BNP was 89.30% with kappa value of 0.675 suggesting substantial agreement between the two tests. The positive and negative predictive value was estimated at 0.765 and 0.925, respectively. It is concluded that NT-Pro BNP and NO may be an alternate diagnostic tool for diagnosis of cardiomyopathy where the facility of echocardiography is not available.
کلیدواژه‌ها
Cardiomyopathy؛ Echocardiography؛ N-terminal pro-brain natriuretic peptide؛ Nitric oxide
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