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THE EFFECT OF β-GLUCAN ON PROLACTIN SECRETION IN GH3/B6 CELLS | ||
| Iranian Journal of Science | ||
| مقاله 1، دوره 31، شماره 3، اسفند 2007، صفحه 223-229 اصل مقاله (202.99 K) | ||
| نوع مقاله: Regular Paper | ||
| شناسه دیجیتال (DOI): 10.22099/ijsts.2007.2338 | ||
| نویسندگان | ||
| H. SEPEHRI* ؛ L. DELPHI؛ Y. RASSOULI | ||
| Animal Physiology Department, School of Biology, College of Science, University of Tehran, I. R. of Iran | ||
| چکیده | ||
| It is well known that several plant extracts have a lactogenic effect. This response may be induced through the stimulation of prolactin release from lactotrope cells. A partial purification of the active compound indicated that it is rich in pectin and β-glucan. These materials stimulate secretion of prolactin from hypophyseal fragments. In the present study, the effect of β-Glucan on the secretion of prolactin from GH3/B6 pituitary tumor cells has been investigated. These cells are good tools for studying the direct effect of β-glucan on prolactin secretion. The different concentrations of β-glucan (50, 100 and 200 μg/ml) increased secretion of prolactin within 24 hours of incubation in GH3/B6 media. Moreover, the secretion of prolactin was significantly elicited at 100 and 200 μg/ml of β-glucan incubation after 48 hours. These results suggest that β-glucan can affect the synthesis and/or release of prolactin, a hormone that plays many important physiological roles from GH3/B6 pituitary tumor cells. | ||
| کلیدواژهها | ||
| Lactotropes؛ prolactin؛ GH3/B6 cells؛ β-glucan | ||
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