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HETTA, M., HASSAN, S., ABDEL-TAWAB, S., BASTAWY, M., MAHMOUD, B.. (1388). HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS. , 33(4), 287-297. doi: 10.22099/ijsts.2009.2225
M. HETTA; S. HASSAN; S. ABDEL-TAWAB; M. BASTAWY; B. MAHMOUD. "HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS". , 33, 4, 1388, 287-297. doi: 10.22099/ijsts.2009.2225
HETTA, M., HASSAN, S., ABDEL-TAWAB, S., BASTAWY, M., MAHMOUD, B.. (1388). 'HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS', , 33(4), pp. 287-297. doi: 10.22099/ijsts.2009.2225
HETTA, M., HASSAN, S., ABDEL-TAWAB, S., BASTAWY, M., MAHMOUD, B.. HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS. , 1388; 33(4): 287-297. doi: 10.22099/ijsts.2009.2225

HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS

Iranian Journal of Science
مقاله 1، دوره 33، شماره 4، اسفند 2009، صفحه 287-297    اصل مقاله (363.25 K)
نوع مقاله: Regular Paper
شناسه دیجیتال (DOI): 10.22099/ijsts.2009.2225
نویسندگان
M. HETTA1؛ S. HASSAN* 2؛ S. ABDEL-TAWAB3؛ M. BASTAWY4؛ B. MAHMOUD5
1Pharmacognosy Department, Faculty of Pharmacy, Beni Suef Univ., Egypt
2Botany Department, Faculty of Science, Beni Suef Univ., Egypt
3Zoology Department, Faculty of Science, Beni Suef Univ., Egypt
4Chemistry Department, Faculty of Science, Beni Suef Univ., Egypt
5Biochemistry Department, Faculty of Science, Beni Suef Univ., Egypt
چکیده
The polysaccharides of Acanthophora spicifera and Cystoseira trinode were isolated and their
components identified using different chemical and spectral techniques. Their effects were evaluated for the
first time on hyperlipidemic rats. Atorvastatin Ca (Lipitor®) was used as a reference drug. Results revealed
that the polysaccharides isolated were of sulfate type. Acanthophora spicifera lowered the level of total serum
lipids, total cholesterol (TC), triglycerides (TG) and low-density lipoproteins (LDL-C) by 48%, 49.6%, 63%
and 80.6% respectively. High-density lipoproteins (HDL-C) level was elevated by 1.14 fold. For Cystoseira
trinode total lipids, TC, TG and LDL-C were decreased by 25.5%, 49%, 51% and 91% respectively. The level
of HDL-C was elevated by 1.5 fold in comparison with the hyperlipidemic rats. The histopathological results
proved the ameliorated effect after using the isolated polysaccharides of both algae. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were decreased in hypercholesterolemic groups by values of 63%, 34% and 45%, respectively when treated with A. spicifera extract. The treatment with C. trinode extract and Atorvastatin exhibited a noticeable amelioration in activity with hypercholesterolemic groups as compared to their corresponding controls.
کلیدواژه‌ها
Acanthophora spicifera؛ Cystoseira trinode؛ sulfated polysaccharides؛ hypolipidaemic؛ Histopathology؛ biochemical parameters
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