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Effects of associated SCF and G-CSF on liver injury two weeks after liver damage: A model induced by thioacetamide administration | ||
| Molecular Biology Research Communications | ||
| مقاله 5، دوره 3، شماره 2، شهریور 2014، صفحه 141-147 اصل مقاله (340.75 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22099/mbrc.2014.2194 | ||
| نویسندگان | ||
| Mohsen Esmaili1؛ Durdi Qujeq* 2؛ Ali Asghar Yoonesi1؛ Farideh Feizi3؛ Mohammad Ranaee4 | ||
| 1Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| 2Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran | ||
| 3Department of Anatomical Sciences, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| 4Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| چکیده | ||
| The present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathology- cal examinations were performed on serum and liver specimens. At the end of the treatment period, the rats were anesthetized with ether, serum was collected and sections of randomly selected fixed liver specimens from each group were embedded in paraffin and processed for light microscopy by staining individual sections with hematoxylin-eosin (HE) stain. Administration of a combination of G-CSF+SCF was carried out two weeks after the TAA treatment. Livers of rats treated with TAA alone exhibited damage, which was significantly less in the group treated with the combination of SCF and G-CSF. Albumin level was 2.35 (g/dl) in the G-CSF+SCF and 1.03 in the TAA-alone group. These differences were statistically significant (P0.05). The albumin level was 2,35 (g/dl) in the G-CSF +SCF and versus 1.03 in the TAA-alone group. These differences in the albumin level were statistically significant (P0.05). | ||
| کلیدواژهها | ||
| Granulocyte colony–stimulating factor؛ Liver injury؛ Stem cell factor؛ Thioacetamide | ||
| مراجع | ||
|
1.Li N, Zhang L, Li H, Fang B. Human CD34
+ cells mobilized by granulocyte colony-stimulating factor ameliorate radiation-induced liver damage in mice. Stem Cell Res Ther 2010;1:1-8.
2.Zhang L, Kang W, Lei Y , Han Q, Zhang G, Lv Y, Li Z , Lou S, Liu Z. Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with d-galactosamine-induced acute liver failure. Toxicol Lett 2011;204:92-99.
3.Takayama H, Miyake Y, Nouso K, Ikeda F, Shiraha H, Takaki A, Kobashi H, Yamamoto K. Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure. J Gastroenterol Hepatol 2011;26:116-121.
4.Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Mobilized bone marrow cells repair the infracted heart , improving function and survival. Proc Natl Acad Sci USA 2001;98:10344-10349.
5.Andrews RG, Briddell RA, Knitter Gh, Rowley SO, Appelbaum FR, Mc Niece IK. Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in non human primates. Blood 1995;85:15-20.
6.Hunter AL, Holscher MA, Neal RA. Thioacetamide-induced hepatic necrosis: I. Involvement of the mixed function oxidase enzyme system. J Pharmacol Exp Ther 1977;200:439-448.
7.Porter WR, Neal RA. Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Drug Metab Dispos 1978;6:379-388.
8.Fitzhugh OG, Nelson AA. Liver tumors in rats fed thiourea or thioacetamide. Science1948;108:626-628.
9.Trennery PN, Waring RH. Early changes in thioacetamide induced liver damage.
Toxicol Lett 1983;19:299-307.
10. Qujeq D, Abassi R, Faeizi F, Parsian H, Sohan-Faraji A, Taheri H, Tatar M, Elmi MM, Halalkhor S. Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon tetrachloride–induced liver damage in experimental model. Toxicol Ind Health 2012;29:498-503.
11. Qujeq D, Abassi R, Faeizi F, Parsian H, Tahhery H, Halallkhor S. Effect of granulocyte colony-stimulating factor on liver injury induced by CCl
4: A correlation between biochemical parameter. Kuwait Med J 2012;44:46-49.
12. Qujeq D, Abassi R, Faeizi F, Parsian H, Faraji A, Tatar M, Elmi M, Halalkhor S, Tahhery H. Assessment effect of granulocyte colony-stimulating factor in experimental models of liver injury. Sci Res Essays 2011;6:4646-4650.
13. Liu F, Pan X, Chen C, Jiang D, Cong X, Fei R, Wei L. Hematopoietic stem cells mobilized by granulocyte colony-stimulating factor partly contribute to liver graft regeneration after partial orthotopic liver transplantation. Liver Transpl 2006;12: 1129-1137.
14. Ekam VS, Johnson JT, Dasofunjo K, Odey MO, Anyahara SE. Total protein, albumin and globulin levels following the administration of activity directed fractions of
Vernonia amygdalina during acetaminophen induced hepatotoxicity in wistar rats .Ann Biol Res 2012;3:5590-5594.
15. Yoonesi A, Qujeq D, Esmaili M, Feizi F. Effects of combination of G-CSF and SCF one week prior to liver injury in acute liver damage model induced by thioacetamide admistration. Res Mol Med 2014,1:1-5.
16. Theocharis SE, Papadimitriou LJ, Retsou ZP, Margeli AP, Ninos SS, Papadimitriou JD. Granulocyte colony stimulating factor administration ameliorates liver regeneration in animal model of fulminant hepatic failure and encephalopathy. Dig Dis Sci 2003;48:1797-1803.
17. Yannaki E, Athanasiou E, Xagorari A, Constantinou V, Batsis I, Kaloyannidis P, Proya E, Anaqnostopoulos A, Fassas A. G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Exp Hematol 2005;33: 108-119.
18. Theocharis SE, Margeli AP, Kittas CN. Effect of granulocyte colony-stimulating-factor administration on tissue regeneration due to thioacetamide-induced liver injury in rats. Dig Dis Sci 1999;44:1990-1996.
19. Caraceni P, Giannone F, Catani L, Talarico S, Pertosa M, Domenicali M, Fogli M, Principe A, Trevisani F, Baccarani M, Bernardi M, Lemoli RM. Liver, pancreas and biliary tract effects of granulocyte colony stimulating-factor in a rat model of acute liver injury. Dig Liver Dis 2007;39:943-951. | ||
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