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Zendehdel, M., Allahdini, P., Safarpour, E., Abrehdari, Z., Pourrahimi, M., Mazaheri Nezhad Fard, R.. (1392). Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain. , 14(4), 341-344. doi: 10.22099/ijvr.2013.1832
M. Zendehdel; P. Allahdini; E. Safarpour; Z. Abrehdari; M. Pourrahimi; R. Mazaheri Nezhad Fard. "Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain". , 14, 4, 1392, 341-344. doi: 10.22099/ijvr.2013.1832
Zendehdel, M., Allahdini, P., Safarpour, E., Abrehdari, Z., Pourrahimi, M., Mazaheri Nezhad Fard, R.. (1392). 'Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain', , 14(4), pp. 341-344. doi: 10.22099/ijvr.2013.1832
Zendehdel, M., Allahdini, P., Safarpour, E., Abrehdari, Z., Pourrahimi, M., Mazaheri Nezhad Fard, R.. Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain. , 1392; 14(4): 341-344. doi: 10.22099/ijvr.2013.1832

Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain

Iranian Journal of Veterinary Research
مقاله 10، دوره 14، شماره 4 - شماره پیاپی 45، 2013، صفحه 341-344    اصل مقاله (214 K)
نوع مقاله: Short paper
شناسه دیجیتال (DOI): 10.22099/ijvr.2013.1832
نویسندگان
M. Zendehdel* 1؛ P. Allahdini2؛ E. Safarpour3؛ Z. Abrehdari2؛ M. Pourrahimi1؛ R. Mazaheri Nezhad Fard4
1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
4Rastegar Reference Laboratory, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
چکیده
The aim of this study was to examine the anti-inflammatory effects of co-administration of growth
hormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),
interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mouse
brain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline, GHRP-2
(100 μg/kg), GH (25 μg/kg) or GHRP-2 + GH, 30 min before the intraperitoneal injection of LPS (5 mg/kg).
Then, inflammation was induced by the intraperitoneal injection of LPS. The control animals received sterile
saline in the first and second injections. Changes in the expression level of TNF-α, IL-6 and iNOS genes
were studied in the mouse brain by a semi quantitative RT-PCR method. The results of this study showed
that GHRP-2 or GH significantly decreased the expression of TNF-α and IL-6 genes in brain 2 h after the
injection of LPS. Co-administration of GHRP-2 and GH markedly reduced the expression of TNF-α and IL-6
genes. LPS had no effect on the expression of iNOS gene in brain. The data suggest that co-administration of GHRP-2 and GH has a protective effect in brain inflammation induced by LPS through inhibition of TNF-α
and IL-6.
کلیدواژه‌ها
LPS؛ GHRP-2؛ GH؛ Brain؛ Mouse
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