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Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 11، دوره 9، شماره 3 - شماره پیاپی 24، 2008، صفحه 266-270 اصل مقاله (44.18 K) | ||
| نوع مقاله: Short paper | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2008.1735 | ||
| نویسندگان | ||
| H. Rajaian* 1؛ M. Fazeli1؛ J. Jalaee2 | ||
| 1Department of Pharmacology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 2Laboratory of Pharmacology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| چکیده | ||
| Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Noncompartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg.min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog. | ||
| کلیدواژهها | ||
| pharmacokinetics؛ Tetracycline؛ dog | ||
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