| تعداد نشریات | 24 |
| تعداد شمارهها | 874 |
| تعداد مقالات | 7,803 |
| تعداد مشاهده مقاله | 14,223,050 |
| تعداد دریافت فایل اصل مقاله | 12,165,471 |
A preliminary study on some potential toxic effects of Rosa damascena Mill | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 8، دوره 14، شماره 3 - شماره پیاپی 44، 2013، صفحه 232-236 اصل مقاله (91.56 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2013.1686 | ||
| نویسندگان | ||
| M. Akbari1؛ H.R. Kazerani* 2؛ A. Kamrani3؛ M. Mohri3 | ||
| 1Graduated from Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| 2Department of Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| چکیده | ||
| Rosa damascena has been traditionally used as an herbal medicine for different therapeutic purposes. In order to preliminarily study the probable toxic effects of the plant, its infusion was orally administered to 5 groups of 5 dogs at doses 0.5-8 times that of human use in traditional medicine (90-1440 mg/kg/d) for 10 successive days. The dogs in the control group (n=4) received placebo. Serum levels of urea, creatinine, alkaline phosphatase (ALP), alanine aminotransferase (ALT), bilirubin, albumin and protein were measured in all experimental groups at days 0, 1, 3, 7 and 10. Except for a transient increase in bilirubin levels (day 3) and a rise in serum ALT at day 10, both with the highest dose of the treatment, there were no statistical differences between different experimental groups compared to the control. The results suggest minimal nephrotoxic or hepatotoxic effects for the infusion of R. damascena, however, the medication may be hepatotoxic at extraordinary high doses. | ||
| کلیدواژهها | ||
| Damask rose؛ Rosa damascena؛ Herbal medicine؛ Serum enzymes | ||
|
آمار تعداد مشاهده مقاله: 2,512 تعداد دریافت فایل اصل مقاله: 4,124 |
||