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Gohil, P. V., Patel, U. D, Bhavsar, S. K., Thaker, A. M.. (1387). Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration. , 10(1), 33-37. doi: 10.22099/ijvr.2009.1086
P. V. Gohil; U. D Patel; S. K. Bhavsar; A. M. Thaker. "Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration". , 10, 1, 1387, 33-37. doi: 10.22099/ijvr.2009.1086
Gohil, P. V., Patel, U. D, Bhavsar, S. K., Thaker, A. M.. (1387). 'Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration', , 10(1), pp. 33-37. doi: 10.22099/ijvr.2009.1086
Gohil, P. V., Patel, U. D, Bhavsar, S. K., Thaker, A. M.. Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration. , 1387; 10(1): 33-37. doi: 10.22099/ijvr.2009.1086

Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration

Iranian Journal of Veterinary Research
مقاله 5، دوره 10، شماره 1 - شماره پیاپی 26، 2009، صفحه 33-37    اصل مقاله (110.52 K)
نوع مقاله: Full paper (Original article)
شناسه دیجیتال (DOI): 10.22099/ijvr.2009.1086
نویسندگان
P. V. Gohil؛ U. D Patel؛ S. K. Bhavsar* ؛ A. M. Thaker
Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat State, India
چکیده
Pharmacokinetics of ceftriaxone was studied in buffalo calves (Bubalus bubalis) after single intravenous
and intramuscular administration of 10 mg/kg body weight. The drug concentrations in plasma samples were
measured by high performance liquid chromatography with UV detection. Following intravenous
administration, the drug was rapidly distributed (Cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; Vdarea: 0.48 ± 0.05 L/kg) and eliminated (t1/2β: 1.27 ± 0.04 h) from the body with a clearance rate of 4.40 ± 0.44 ml/min.kg. Following intramuscular administration, the peak plasma concentration of the drug was 15.8 ± 2.4 μg/ml at 0.5 h and the drug was detected up to 12 h. The drug was rapidly absorbed from the site of injection (t1/2ka: 0.35 ± 0.01 h), widely distributed (Vdarea: 1.53 ± 0.2 L/kg) and slowly eliminated from the body (t1/2β: 4.38 ± 0.4 h; ClB: 4.01 ± 0.30 ml/min.kg). The bioavailability of ceftriaxone was 70.2 ± 2.0% following intramuscular injection. Intramuscular injection of ceftriaxone has favourable pharmacokinetics and moderate bioavailability in buffalo calves and can be used for susceptible infections in calves.
کلیدواژه‌ها
pharmacokinetics؛ Ceftriaxone؛ Buffalo calves؛ Intravenous؛ Intramuscular
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