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Pharmacokinetics of ceftriaxone in buffalo calves (Bubalus bubalis) following intravenous and intramuscular administration | ||
| Iranian Journal of Veterinary Research | ||
| مقاله 5، دوره 10، شماره 1 - شماره پیاپی 26، 2009، صفحه 33-37 اصل مقاله (110.52 K) | ||
| نوع مقاله: Full paper (Original article) | ||
| شناسه دیجیتال (DOI): 10.22099/ijvr.2009.1086 | ||
| نویسندگان | ||
| P. V. Gohil؛ U. D Patel؛ S. K. Bhavsar* ؛ A. M. Thaker | ||
| Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat State, India | ||
| چکیده | ||
| Pharmacokinetics of ceftriaxone was studied in buffalo calves (Bubalus bubalis) after single intravenous and intramuscular administration of 10 mg/kg body weight. The drug concentrations in plasma samples were measured by high performance liquid chromatography with UV detection. Following intravenous administration, the drug was rapidly distributed (Cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; Vdarea: 0.48 ± 0.05 L/kg) and eliminated (t1/2β: 1.27 ± 0.04 h) from the body with a clearance rate of 4.40 ± 0.44 ml/min.kg. Following intramuscular administration, the peak plasma concentration of the drug was 15.8 ± 2.4 μg/ml at 0.5 h and the drug was detected up to 12 h. The drug was rapidly absorbed from the site of injection (t1/2ka: 0.35 ± 0.01 h), widely distributed (Vdarea: 1.53 ± 0.2 L/kg) and slowly eliminated from the body (t1/2β: 4.38 ± 0.4 h; ClB: 4.01 ± 0.30 ml/min.kg). The bioavailability of ceftriaxone was 70.2 ± 2.0% following intramuscular injection. Intramuscular injection of ceftriaxone has favourable pharmacokinetics and moderate bioavailability in buffalo calves and can be used for susceptible infections in calves. | ||
| کلیدواژهها | ||
| pharmacokinetics؛ Ceftriaxone؛ Buffalo calves؛ Intravenous؛ Intramuscular | ||
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